Key Difference – Basophil vs Eosinophil
Let us first briefly look at the composition of blood, to understand the Difference Between Basophil and Eosinophil clearly. Blood is mainly composed of white blood cells, red blood cells, platelets, and plasma. Plasma is the fluid part of the blood and represents more than half of blood’s volume. White blood cells make up about 1% of the entire blood volume, and red blood cells make up about 45%. The white blood cells or leukocytes are classified into cells with or without granules. Granular leukocytes include neutrophils, eosinophil and basophil and nongranular leukocytes include lymphocytes and monocytes. The key difference between basophil and eosinophil is that Basophils can stimulate inflammation responses by releasing heparin, histamine, and serotonin while Eosinophils provide important defense against parasites by phagocytosis and producing antihistamines.
What is Basophil?
Basophils are granular leukocytes with an S-shaped multi-lobed nucleus and are similar to the size of eosinophils. These cells stimulate inflammation responses by releasing heparin, histamine, and serotonin. Biologists believe that basophils are produced and matured in the bone marrow. Certain morphological and functional features of basophils are equal to mast cells, which are common in tissues. Basophils are hardly seen in the blood of healthy humans, because once they release, they circulate for a few hours in the blood and migrate to the tissues where they last a few days. Basophils have relatively few granules, which are water soluble. Therefore, identifying basophils in blood is quite difficult. However, when basic stains are used to identify, the cytoplasm of the basophils stain blue in color.
What is Eosinophil?
Eosinophils are bone marrow derived granular leukocytes with two-lobed nucleus. They provide an important defense against parasites by phagocytosis and produce antihistamines. When acid stains are used, the cytoplasm of the eosinophil stains in red. Usually, 1% to 5% of white blood cells are eosinophils. Very low number of eosinophils are found in the blood circulation of healthy persons because these cells are primarily tissue-dwelling cells.
What is the difference between Basophil and Eosinophil?
Characteristics of Basophil and Eosinophil
Nucleus of cell
Basophil: Basophil has S-shaped multi-lobed nucleus.
Eosinophil: Eosinophil has two-lobed nucleus.
Basophil: Cytoplasm of basophil stains blue in basic stains.
Eosinophil:Cytoplasm of eosinophil stains red in acid stains.
Basophil: 0.5% or less of leukocytes are basophils.
Eosinophil: 1-5 % of leukocytes are eosinophils.
Basophil: Basophils can stimulate inflammation responses by releasing heparin, histamine, and serotonin.
Eosinophil: Eosinophils provide important defense against parasites by phagocytosis and produce antihistamines.Image Courtesy: “Blausen 0352 Eosinophil” by BruceBlaus. When using this image in external sources it can be cited as:Blausen.com staff. “Blausen gallery 2014”. Wikiversity Journal of Medicine. DOI:10.15347/wjm/2014.010. ISSN 20018762. – Own work. (CC BY 3.0 ) via Wikimedia Commons “Blausen 0077 Basophil” by BruceBlaus. When using this image in external sources it can be cited as:Blausen.com staff. “Blausen gallery 2014”. Wikiversity Journal of Medicine. DOI:10.15347/wjm/2014.010. ISSN 20018762. – Own work. (CC BY 3.0) via Wikimedia Commons