Difference Between Fibroblast and Fibrocyte

Fibroblast vs Fibrocyte

Fibroblast and fibrocyte are two different states of the same cells, which are mainly associated with the production of various types of extracellular matrix components in tissues.  They differ in their activeness and roles played in the biological system. However, both cells have the ability to differentiate into myofibroblasts, which are found especially in the places, where body tissues are under mechanical stress.

What is Fibroblast?

Fibroblasts are spindle-shaped flat cells with minute processes spreading out of the cell body. The cells have ellipsoidal, flattened nucleus with finely distributed chromatin and also contain 1-2 nucleoli. When fibroblasts are active, cellular organelles like Golgi apparatus and rough endoplasmic reticulum become more prominent.

Fibroblasts are derived from mesenchymal stem cells and are associated with extracellular matrix, and the cellular components of parenchyma. However, these cells can also be derived from fibrocytes, which are considered as the inactive form of fibroblasts.

The main role of the fibroblasts is to produce various extracellular matrix including proteoglycans, collagens, proteolytic enzymes, growth factors, and certain signaling molecules like cytokines. In the human heart, these cells involve in cellular interaction with other fibroblasts, myocytes and endothelial cells. In addition, these cells contribute to chemical, mechanical and electrical signaling in the heart.

What is Fibrocyte?

Fibrocytes cells are known as bone marrow- derived mesenchymal progenitor cells that basically act as the precursor cells of fibroblasts. The interest on fibrocytes has been rapidly increased over the last decade due to their important roles in the biological system. These cells mainly contribute to wound repair and fibrosis due to their ability of differentiation into their active form; fibroblasts. Additionally, fibrocytes also involve in certain immune responses as well as the deposition of collagen fibers.

What is the differences between Fibroblast and Fibrocyte?

• Fibrocytes are considered as the precursor cells of fibroblasts.

• Fibrocytes are originated from multipotent progenitors, whereas both fibrocytes and mesenchymal stem cells can give rise to fibrocytes.

• Fibrocytes are considered as less active cells, whereas fibroblasts are considered as more active cells.

• Fibroblasts mainly produce extracellular components such as proteoglycans, collagens, proteolytic enzymes, growth factors and certain signaling molecules like cytokines, while fibrocytes involve in certain immune response, deposition of collagen, and wound repair.