The key difference between hydrochlorothiazide and chlorthalidone is that hydrochlorothiazide has a shorter half-life and may require multiple daily doses for comparable effects, while chlorthalidone has a longer half-life, provides a more sustained and potent effect, and often requires once-daily dosing. Hydrochlorothiazide and chlorthalidone are thiazide diuretics used to treat hypertension (high blood pressure) and […]