The key difference between hydrochlorothiazide and chlorthalidone is that hydrochlorothiazide has a shorter half-life and may require multiple daily doses for comparable effects, while chlorthalidone has a longer half-life, provides a more sustained and potent effect, and often requires once-daily dosing. Hydrochlorothiazide and chlorthalidone are thiazide diuretics used to treat hypertension (high blood pressure) and […]
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