The key difference between Doxycycline Hyclate and Monohydrate is that Doxycycline Hyclate (trade names: Vibramycin, Periostat, Acticlate) is highly soluble in water whereas Doxycycline Monohydrate (trade names: Vibramycin monohydrate, Monodox, Monodoxyne NL) is only slightly soluble in water.
Doxycycline Hyclate and monohydrate are two forms of medicinal drugs useful to treat certain bacterial infections. Most common infections are dental, skin, respiratory and urinary tract infections. Other than the water solubility, these drugs are different from each of their cost as well. Doxycycline monohydrate is cheaper than the hyclate salt.
What is Doxycycline Hyclate?
Doxycycline Hyclate is a salt of doxycycline. It is a form of a drug that is useful in treating bacterial infections such as dental infections, skin infections, and urinary tract infections. In addition, this drug can treat acne, Lyme disease, Malaria and some sexually transmitted diseases. We can classify it as an antibacterial drug. However, it cannot treat any viral infections (treats only bacterial infections).
The route of administration of Doxycycline Hyclate is via mouth on an empty stomach. It does not work well if we take it with food or drink. This drug is expensive than doxycycline monohydrate.
What is Doxycycline Monohydrate?
Doxycycline monohydrate is a salt of doxycycline that is used to treat bacterial infections such as dental, skin, respiratory and urinary tract infections. In addition, this drug can treat acne, Lyme disease, Malaria and some sexually transmitted diseases. The method of action of this drug is similar to that of doxycycline hyclate. It is cheaper than other doxycycline drugs. It is slightly water-soluble.
What is the Difference Between Doxycycline Hyclate and Monohydrate?
Doxycycline Hyclate is a salt of doxycycline that has the trade names Vibramycin, Periostat and Acticlate. Furthermore, Doxycycline monohydrate is a salt of doxycycline that has the trade names Vibramycin monohydrate, Monodox, and Monodoxyne NL .
Furthermore, Doxycycline Hyclate is highly soluble in water while Doxycycline monohydrate is only slightly soluble in water. Doxycycline Hyclate is expensive with comparison to other salt forms of doxycycline. However, Doxycycline monohydrate is cheaper compared to other salt forms of doxycycline.
Summary – Doxycycline Hyclate vs Monohydrate
Doxycycline is a form of drug that is useful in treating different infections. Doxycycline Hyclate and monohydrate are salts of this drug. The difference between Doxycycline Hyclate and monohydrate is that doxycycline hyclate is highly water soluble whereas doxycycline monohydrate is slightly water soluble.
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2. “Doxycycline Hyclate vs. Monohydrate.” Study.com, Study.com. Available here
3. “Doxycycline.” Wikipedia, Wikimedia Foundation, 23 May 2018. Available here
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