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Difference Between Job’s Method and Mole Ratio Method

November 21, 2019 Posted by Madhu

The key difference between Job’s method and mole ratio method is that in Job’s method, the molar concentrations of reactants are held a constant, while in mole ratio method, the molar concentration of a reactant is kept constant and the molar concentration of other reactants varies.

Job’s method is a process we can use in analytical chemistry to determine the stoichiometry of binding of different chemical species. Mole ratio method is an alternative method for the Job’s method. However, both techniques are useful in different occasions.

CONTENTS

1. Overview and Key Difference
2. What is Job’s Method 
3. What is Mole Ratio Method
4. Side by Side Comparison – Job’s Method vs Mole Ratio Method in Tabular Form
5. Summary

What is Job’s Method?

Job’s method is an analytical technique we can use to determine the stoichiometry of a binding event by keeping the molar concentrations of reactants constant. This method is named after the scientist Paul Job, who developed the technique in 1928.

Let us consider an example to understand the method. Consider a reaction mixture which has two chemical species (B and D) that can bind with each other. The stoichiometry for this binding reaction can be obtained using the Job’s method. This means we don’t know exactly how much of B binds with D, or vice versa. Using this method, we can find these exact amounts. For this determination, we have to keep the sum of the molar concentrations of binding partners constant. However, their molar fractions may vary. Therefore, we can run an experiment in order to get readings for the mole fraction and the physical property that we are going to measure. i.e. UV absorbance.

What is Mole Ratio Method?

Mole ratio method is an alternative method for Job’s method. In this method, the molar concentration of one reactant varies, and the molar concentration of other reactant is constant. Here also, we can determine the stoichiometry of a binding event by plotting a graph using the molar fractions and a physical property that varies with the formation of the complex by binding two chemic species.

Difference Between Job's Method and Mole Ratio Method

Figure 01: Use of Mole Ratio Method in the Synthesis of Nano Titanium Dioxide

Generally, the physical property is UV absorption (ex: reactants cannot absorb UV rays while newly formed complex can).

What is the Difference Between Job’s Method and Mole Ratio Method?

Job’s method is a process we can use in analytical chemistry to determine the stoichiometry of binding of different chemical species. The key difference between Job’s method and mole ratio method is that in Job’s method the molar concentrations of reactants are held a constant while, in mole ratio method, the molar concentration of a reactant is kept constant and the molar concentration of other reactant varies. Job’s method is the most common method for the determination of stoichiometry of binding event while mole ratio method is an alternative method for Job’s method.

Below infographic summarizes the difference between Job’s method and mole ratio method.

Difference Between Job's Method and Mole Ratio Method in Tabular Form

Summary – Job’s Method vs Mole Ratio Method

Job’s method is a process we can use in analytical chemistry to determine the stoichiometry of binding of different chemical species. Mole ratio method is an alternative method for Job’s method. The key difference between Job’s method and mole ratio method is that in Job’s method the molar concentrations of reactants are held constant while in mole ratio method the molar concentration of a reactant is kept constant and the molar concentration of other reactant varies.

Reference:

1. “Jobs Method.” Scribd, Available here.
2. “Job Plot.” Wikipedia, Wikimedia Foundation, 25 Sept. 2019, Available here.
3. “Mole-Ratio Method for Determining Metal-Ligand Stoichiometry.” Image and Video Exchange Forum, Available here.

Image Courtesy:

1. “Synthesis of nano-TiO2 – stellerite composite” By Vicente Neto – Own work (CC BY 4.0) via Commons Wikimedia

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Filed Under: Analytical Chemistry

About the Author: Madhu

Madhu is a graduate in Biological Sciences with BSc (Honours) Degree and currently persuing a Masters Degree in Industrial and Environmental Chemistry. With a mind rooted firmly to basic principals of chemistry and passion for ever evolving field of industrial chemistry, she is keenly interested to be a true companion for those who seek knowledge in the subject of chemistry.

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