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What is the Difference Between Hydroxyzine HCL and Hydroxyzine Pamoate

January 14, 2022 Posted by Madhu

The key difference between hydroxyzine Hcl and hydroxyzine pamoate is that hydroxyzine Hcl is available as tablets and liquids, whereas hydroxyzine pamoate is available as capsules and liquid.

Hydroxyzine is a medication that is useful in treating itching that is caused by allergies. It is a useful antihistamine medication that can work by blocking histamine, which is produced by our body during an allergic reaction. This medication is useful for short-term treatment for anxiety and helps patients to feel sleepy or relaxed before and after surgery.

The route of administration of this medication is oral. It is available in the liquid form, as tablets or capsules that we can take by mouth. When taking the liquid form, it is very important to get a measuring spoon rather than a normal household spoon to measure the correct dose. In addition, the dose of the medication depends on the age, medical condition, and response to the treatment.

CONTENTS

1. Overview and Key Difference
2. What is Hydroxyzine HCL  
3. What is Hydroxyzine Pamoate 
4. Hydroxyzine HCL vs Hydroxyzine Pamoate in Tabular Form
5. Summary – Hydroxyzine HCL vs Hydroxyzine Pamoate 

What is Hydroxyzine HCL?

Hydroxyzine Hcl is a medication that comes in tablets or liquid form and is useful in treating itching caused by allergies. It is also useful in helping to control anxiety and tension that is caused by nervous and emotional conditions. Moreover, this medication can be helpful in controlling and producing sleep before surgery.

Hydroxyzine HCL vs Hydroxyzine Pamoate in Tabular Form

The brand name of this drug is ATARAX. It is essentially a prescription medicine. This drug belongs to the class of antihistamines. There can be some severe side effects from this medication, including mood changes, restlessness, confusion, shaking, difficulty in urinating, and a fast heartbeat. The common side effects are drowsiness, dizziness, constipation, etc.

Chemically, hydroxyzine Hcl is a form of ethanol dihydrochloride. It is produced as a white, odorless powder that is highly water-soluble. The active ingredients of the tablets of this drug include anhydrous lactose, colloidal silicon dioxide, hypromellose, etc.

What is Hydroxyzine Pamoate?

Hydroxyzine pamoate is a medication that comes in capsules or liquid form and is useful in treating itching caused by allergies. The brand name of this drug is VISTARIL. It is an antihistamine used to treat anxiety and tension. We can use it with other medications in order to induce sleep before surgery. This drug is slightly more popular than hydroxyzine Hcl.

Hydroxyzine HCL and Hydroxyzine Pamoate - Side by Side Comparison

The chemical formula of hydroxyzine pamoate is C44H43ClN2O8. There can be some side effects of this drug, which include drowsiness, headache, dry mouth, and skin rash. However, there can be some serious side effects as well, including fast or pounding heartbeats, headache with chest pain, severe dizziness, fainting, and convulsions.

Chemically, it is a diethylenediamine salt of a methylene carboxylic acid. There are some inert ingredients in this drug including, hard gelatin, magnesium stearate, sodium lauryl sulfate, starch, and sucrose. This medication is available as a capsule or as an oral suspension.

What is the Difference Between Hydroxyzine HCL and Hydroxyzine Pamoate?

Hydroxyzine Hcl and pamoate are types of antihistamine drugs. The key difference between hydroxyzine Hcl and hydroxyzine pamoate is that hydroxyzine Hcl is available as tablets and liquids, whereas hydroxyzine pamoate is available as capsules and liquid. Moreover, hydroxyzine Hcl is a form of ethanol dihydrochloride while hydroxyzine pamoate is a diethylenediamine salt of a methylene carboxylic acid.

Below is a summary of the difference between hydroxyzine Hcl and hydroxyzine pamoate in tabular form for side by side comparison.

Summary – Hydroxyzine HCL vs Hydroxyzine Pamoate

Hydroxyzine is a medication that is useful in treating itching that is caused by allergies. Hydroxyzine Hcl and pamoate are types of antihistamine drugs. The key difference between hydroxyzine Hcl and hydroxyzine pamoate is that hydroxyzine Hcl is available as tablets and liquids, whereas hydroxyzine pamoate is available as capsules and liquid.

Reference:

1. “Hydroxyzine Hcl Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing“. Webmd.Com, 2022.

Image Courtesy:

1. “Photo of medicine, health, colors, colours, pain, drug, prescription, pills, shapes, vitamins, tablets, medical, chemistry, drugs, medication, capsules, coated, pharmaceutical, health care, pharmaceutical drug” (CC0) via Pxhere
2. “Bottles, chemicals, colorful, liquid, syringe, container, jar, medicine, pharmacology, still life” (CC0) via Pixino

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Filed Under: Organic Chemistry

About the Author: Madhu

Madhu is a graduate in Biological Sciences with BSc (Honours) Degree and currently persuing a Masters Degree in Industrial and Environmental Chemistry. With a mind rooted firmly to basic principals of chemistry and passion for ever evolving field of industrial chemistry, she is keenly interested to be a true companion for those who seek knowledge in the subject of chemistry.

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