The key difference between hyoscine hydrobromide and hyoscine butylbromide is that hyoscine hydrobromide can cross the blood-brain barrier, whereas hyoscine butylbromide cannot cross the blood-brain barrier.
Hyoscine hydrobromide or scopolamine is a natural or synthetic tropane alkaloid and an anticholinergic drug that is important as a medication in treating motion sickness and postoperative nausea and vomiting. Hyoscine Butylbromide is an organic compound named as scopolamine butylbromide. It is an anticholinergic medication useful in treating crampy abdominal pain, esophageal spasms, renal colic, and bladder spasms.
CONTENTS
1. Overview and Key Difference
2. What is Hyoscine Hydrobromide
3. What is Hyoscine Butylbromide
4. Hyoscine Hydrobromide vs Hyoscine Butylbromide in Tabular Form
5. Summary – Hyoscine Hydrobromide vs Hyoscine Butylbromide
What is Hyoscine Hydrobromide?
Hyoscine hydrobromide or scopolamine is a natural or synthetic tropane alkaloid and an anticholinergic drug that is important as a medication in treating motion sickness and postoperative nausea and vomiting. It is also known as hyoscine or Devil’s Breath.
Figure 01: The Chemical Structure of Hyoscine Hydrobromide
Sometimes, this drug is useful prior to surgery for decreasing saliva. Moreover, it can be used as an injection, and its effects tend to begin in 20 minutes and can last up to 8 hours. Furthermore, we can use this medication orally and also as a transdermal patch.
There are some common side effects related to hyoscine hydrobromide, such as sleepiness, blurred vision, dilated pupils, and dry mouth. Moreover, this medication is not suitable for patients having angle-closure glaucoma or bowel obstruction. It is unclear whether it’s safe for use during pregnancy.
Metabolism of Hyoscine hydrobromide occurs in the liver. Its elimination half-life is about 4.5 hours. The excretion of this medication occurs in the kidney. The chemical formula of Hyoscine hydrobromide C17H21NO4.
Among the number of uses of Hyoscine hydrobromide in medicine, the most important uses include postoperative nausea and vomiting, motion sickness, gastrointestinal spasms, renal or biliary spasms, irritable bowel syndrome, etc.
What is Hyoscine Butylbromide?
Hyoscine Butylbromide is an anticholinergic medication useful in treating crampy abdominal pain, esophageal spasms, renal colic, and bladder spasms. This organic compound is also known as scopolamine butylbromide. Moreover, Hyoscine Butylbromide is useful in improving respiratory secretions at the end of life. We can take this medication orally or as an injection into muscle or vein.
Figure 02: The Chemical Structure of Hyoscine Butylbromide
The most common side effects of this medication are sleepiness, vision changes, dry mouth, rapid heart rate, etc. Moreover, it is unclear whether it’s safe for use during pregnancy. However, it appears to be safe for use during breastfeeding. Moreover, it does not have much effect on the brain since it is an anticholinergic agent.
What is the Difference Between Hyoscine Hydrobromide and Hyoscine Butylbromide?
Hyoscine hydrobromide and hyoscine butylbromide are important anticholinergic drugs. The key difference between hyoscine hydrobromide and hyoscine butylbromide is that hyoscine hydrobromide can cross the blood-brain barrier, whereas hyoscine butylbromide cannot cross the blood-brain barrier.
The below infographic presents the differences between hyoscine hydrobromide and hyoscine butylbromide in tabular form for side by side comparison.
Summary – Hyoscine Hydrobromide vs Hyoscine Butylbromide
Hyoscine hydrobromide is a natural or synthetic tropane alkaloid and an anticholinergic drug that is important as a medication in treating motion sickness and postoperative nausea and vomiting. Hyoscine Butylbromide is an anticholinergic medication useful in treating crampy abdominal pain, esophageal spasms, renal colic, and bladder spasms. The key difference between hyoscine hydrobromide and hyoscine butylbromide is that hyoscine hydrobromide can cross the blood-brain barrier, whereas hyoscine butylbromide cannot cross the blood-brain barrier.
Reference:
1. Stewart, Michael. “Hyoscine Butylbromide Tablets – Buscopan. Side Effects; Dosage.” Patient.info, 19 Oct. 2020.
Image Courtesy:
1. “L-Scopolamin” By NEUROtiker – Own work, Public Domain) via Commons Wikimedia
2. “Butylscopolamine skeletal” By Fvasconcellos 01:29, 19 April 2007 (UTC) – Own work (Public Domain) via Commons Wikimedia