The key difference between tylosin tartrate and tylosin phosphate is tylosin tartrate is better absorbed than tylosin phosphate after oral administration.
Tylosin is a macrolide antibiotic and a bacteriostatic feed additive that is useful in veterinary medicine. This compound has a broad spectrum of activity against Gram-positive organisms and a limited range of Gram-negative organisms. Naturally, we can find it in the fermentation product of Streptomyces fradiae.
CONTENTS
1. Overview and Key Difference
2. What is Tylosin Tartrate
3. What is Tylosin Phosphate
4. Tylosin Tartrate vs Tylosin Phosphate in Tabular Form
5. Summary – Tylosin Tartrate vs Tylosin Phosphate
What is Tylosin Tartrate?
Tylosin tartrate is an organic compound having the chemical formula C50H83NO23. The molar mass of this compound is 1066.2 g/mol. It can be described as a macrolide antibiotic that can be obtained from cultures of Streptomyces fradiae. This drug is highly effective against many microorganisms in animals; however, it does not work in humans. Therefore, it is useful in manufacturing animal drugs as an antibacterial agent. Tylosin tartrate is also known as Fradizine, hydrochloride Tylosin, Tylan, Tylosin, and Tylosin hydrochloride.
Tylosin tartrate has a hydrogen bond donor count of 9, and the hydrogen bond acceptor count of this compound is 24. Moreover, it has a rotatable bond count of 16. The complexity of tylosin tartrate can be given as 1700 degrees, and it has a defined atom stereocenter count of 23.
There are many research studies regarding the antimicrobial activity and effectivity of this drug in animals. These experiments have been carried out mainly using rats and mice. For example, the oral administration of tylosin tartrate into rats (>6200 mg/kg), intravenous administration of this drug into rats (dose is 695 mg/kg), and the administration of this drug subcutaneously into mice (dose is 1354 mg/kg) can cause behavioral effects, convulsions, or effect on seizure threshold.
What is Tylosin Phosphate?
Tylosin phosphate is an organic compound having the chemical formula C46H80NO21P. The molar mass of this compound is 1014.1 g/mol. This compound is also known as Farmazin TB, Pharmasin TB. It has a hydrogen bond donor count of 8 and a hydrogen bond acceptor count of 22. Moreover, the rotatable bond count of tylosin phosphate is 13. The complexity of this compound can be given as 1610 degrees. Moreover, tylosin phosphate has a defined stereocenter count of 2. Similar to tylosin tartrate, tylosin phosphate is also important in manufacturing animal drugs.
Tylosin phosphate can be defined as a macrolide antibiotic that can act as a bacteriostatic drug. Therefore, it is useful in veterinary medicine. Moreover, it has a broad spectrum of activity against Gram-positive organisms and a limited range of Gram-negative organisms.
What is the Difference Between Tylosin Tartrate and Tylosin Phosphate?
In general, tylosin tartrate and tylosin phosphate are used in the manufacture of animal drugs because of their antimicrobial effects. The key difference between tylosin tartrate and tylosin phosphate is that tylosin tartrate is better absorbed than tylosin phosphate after oral administration.
Moreover, the complexity of tylosin tartrate is high, while the complexity of tylosin phosphate is low (1700 and 1610 degrees, respectively). The molar masses of these two compounds also vary depending on the molecular formula; 1066.2 g/mol and 1014.1 g/mol, respectively, for tylosin tartrate and tylosin phosphate.
The below infographic presents the differences between tylosin tartrate and tylosin phosphate in tabular form for side-by-side comparison.
Summary – Tylosin Tartrate vs Tylosin Phosphate
Tylosin tartrate is an organic compound having the chemical formula C50H83NO23. Tylosin phosphate is an organic compound having the chemical formula C46H80NO21P. The key difference between tylosin tartrate and tylosin phosphate is that the absorption of tylosin tartrate is better than that of tylosin phosphate after oral administration.
Reference:
“Tylosin Tartrate.” National Center for Biotechnology Information. PubChem Compound Database, U.S. National Library of Medicine.
Image Courtesy:
1. “Poultry drugs” By ILRI (CC BY-NC-ND 2.0) via Flickr
2. “Animal medication veterinary pharmaceutical bottles” By Jheemstra – Own work (CC BY-SA 3.0) via Commons Wikimedia