The key difference between promethazine hydrochloride and theoclate is that promethazine hydrochloride contains an HCl molecule in association with the promethazine molecule, whereas promethazine theoclate forms as a combination of promethazine, diphenhydramine, and theophylline.
Promethazine can be described as a first-generation antihistamine and antiemetic medication useful in treating allergies, insomnia, and nausea. This medication can also help with some symptoms associated with a common cold and can be used for sedating people with agitation or anxiousness. This medication comes in two forms as promethazine hydrochloride or promethazine HCl and promethazine theoclate.
CONTENTS
1. Overview and Key Difference
2. What is Promethazine Hydrochloride
3. What is Promethazine Theoclate
4. Promethazine Hydrochloride vs Theoclate in Tabular Form
5. Summary – Promethazine Hydrochloride vs Theoclate
What is Promethazine Hydrochloride?
Promethazine hydrochloride is a medication useful in treating and preventing nausea and vomiting related to certain conditions, including surgery, motion sickness, etc. The chemical formula of this compound is C17H20N2S.ClH. The other names for this medication include promethazine HCl and Phenergan. The molar mass of this compound is 320.9 g/mol. This compound is an odorless white to a faint yellow crystalline powder having a bitter taste. A solution of 10% promethazine hydrochloride solution in water usually has a pH of 3.5 – 5.0.
Promethazine hydrochloride can be described as the hydrochloride salt of promethazine. The role of this medication is to act as an antipruritic drug. Besides, it is useful as an H1-receptor antagonist, a local anesthetic, an antiemetic, a sedative, an anti-allergic agent, an anticoronaviral agent, as well as a geroprotector.
The IUPAC name of promethazine hydrochloride is N,N-dimethyl-1-phenothiazin-10-ylpropan-2-amine: hydrochloride. The hydrogen bond donor count of this compound is 1, and the hydrogen bond acceptor count is 3. The rotatable bond count of promethazine hydrochloride is 3. The heavy atom count of promethazine hydrochloride is 21, while the formal charge is zero. However, we can describe the complexity of promethazine hydrochloride as 298. Moreover, the melting point of this compound can range from 446 to 450 degrees Celsius. It has moderate solubility in water.
What is Promethazine Theoclate?
Promethazine theoclate is a medication useful in treating nausea and vomiting related to certain conditions such as surgery or motion sickness. The chemical formula of this compound is C24H27ClN6O2S. Other names for this medication include promethazine 8-chlorotheophyllinate, promethawern, and Avopreg. The molar mass of this compound is 499 g/mol. It is a member of phenothiazines. The IUPAC name of promethazine theolcate is 8-chloro-1,3-dimethyl-7H-purine-2,6-dione;N,N-dimethyl-1-phenothiazin-10-ylpropan-2-amine.
The hydrogen bond donor count of promethazine theoclae is 1, while the hydrogen bond acceptor count is 6. The rotatable bond count of this compound is 3. Moreover, the heavy atom count is 34, while the formal charge is zero. The complexity of promethazine theoclate can be given as 596 degrees.
The chemical structure of promethazine theoclate can be described as a combination of promethazine, diphenhydramine, and theophylline.
What is the Difference Between Promethazine Hydrochloride and Theoclate?
Promethazine can be described as a first-generation antihistamine and antiemetic medication useful in treating allergies, insomnia, and nausea. It comes in two forms as promethazine hydrochloride and promethazine theoclate. The key difference between promethazine hydrochloride and theoclate is that promethazine hydrochloride contains an HCl molecule in association with promethazine molecule whereas promethazine theoclate forms as a combination of promethazine, diphenhydramine, and theophylline.
The following table summarizes the difference between promethazine hydrochloride and theoclate.
Summary – Promethazine Hydrochloride vs Theoclate
Promethazine hydrochloride and promethazine theoclate are medications useful in treating and preventing nausea and vomiting related to certain conditions, including surgery, motion sickness, etc. The key difference between promethazine hydrochloride and theoclate is that promethazine hydrochloride contains an HCl molecule in association with promethazine molecule, whereas promethazine theoclate forms as a combination of promethazine, diphenhydramine, and theophylline.
Reference:
1. “Promethazine Hydrochloride.” National Center for Biotechnology Information. PubChem Compound Database, U.S. National Library of Medicine.
Image Courtesy:
1. “Medicine” By Gaurav Dhwaj Khadka – Own work (CC BY-SA 4.0) via Commons Wikimedia