Kisspeptin-10 and Gonadorelin are both peptides that play important roles in the regulation of reproductive hormones. Peptides are naturally occurring molecules made up of short amino acid chains. Researchers are focusing on how peptides can help manage reproductive health in humans. They have discovered that kisspeptin-10 and gonadorelin-based therapies have substantial potential for the treatment of reproductive disorders.
The key difference between kisspeptin-10 and gonadorelin is their nature. kisspeptin-10 is a naturally occurring hormone in the kisspeptin peptide family that stimulates endogenous GnRH secretion from the hypothalamus, while gonadorelin is a synthetic GnRH used to test the function of gonadotropes of the pituitary.
CONTENTS
1. Overview and Key Difference
2. What is Kisspeptin-10
3. What is Gonadorelin
4. Similarities – Kisspeptin-10 and Gonadorelin
5. Kisspeptin-10 vs Gonadorelin in Tabular Form
6. Summary – Kisspeptin-10 vs Gonadorelin
7. FAQ: Kisspeptin-10 and Gonadorelin
What is Kisspeptin-10?
Kisspeptin-10 is a naturally occurring hormone in the kisspeptin peptide family. It stimulates gonadotropin release in both males and females. Kisspeptin peptides are important in human reproductive physiology. Therefore, the usage of kisspeptin-10 is a potential therapy for infertility.
Figure 01: Kisspeptin-10
The human kisspeptin peptides (kisspeptin-10, -13, -14, and -54) have been named according to the number of constituent amino acids. All these peptides are encoded by a gene called KISS1.
What is Gonadorelin?
Gonadorelin is a form of gonadotropin-releasing hormone (GnRH). It is a synthetic form of GnRH. Gonadorelin is a decapeptide prepared by using solid phase peptide synthesis. Gonadorelin triggers the release of follicle-stimulating hormone and luteinizing hormone from the anterior pituitary.
Figure 02: Gonadorelin
Gonadorelin is used to induce ovulation in women who don’t ovulate regularly due to insufficient GnRH release from the hypothalamus. Additionally, it’s used to assess the function of the hypothalamus and pituitary glands.
Similarities Between Kisspeptin-10 and Gonadorelin
- Kisspeptin-10 and gonadorelin are two peptide hormones.
- Both these molecules have 10 amino acids.
- These molecules can stimulate LH and FSH from the pituitary.
- Both these molecules can be used for the treatment of reproductive disorders.
Difference Between Kisspeptin-10 and Gonadorelin
Definition
- Kisspeptin-10 is a natural hormone that stimulates endogenous GnRH secretion from the hypothalamus.
- Gonadorelin is a synthetic hormone which causes the pituitary gland in the brain to make and secrete the hormones like luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
Commonness
- Kisspeptin-10 is more common and naturally present inside the body.
- Gonadorelin is less common as this is a synthetic form of GnRH.
Synthesis
- Kisspeptin-10 is naturally occurring and is encoded by the gene called KISS1.
- Gonadorelin is a synthetic protein made through solid phase peptide synthesis.
Function
- Kisspeptin-10 stimulates gonadotropin release in mammalians, is used for infertility treatment, can help to raise testosterone levels in males, and is an alternative to testosterone replacement therapy.
- Gonadorelin is used to cause ovulation in women and used to test how well the hypothalamus and the pituitary glands are working.
The following table summarizes the difference between kisspeptin-10 and gonadorelin.
Summary – Kisspeptin-10 vs Gonadorelin
Kisspeptin-10 and gonadorelin are two peptide hormones that are very important in reproductive health. Kisspeptin-10 is a natural hormone in the family of kisspeptin peptides, which stimulates endogenous GnRH secretion from the hypothalamus, while gonadorelin is a synthetic hormone that is the same as gonadotropin-releasing hormone (GnRH), which causes the pituitary gland to release other hormones like LH and FSH. Moreover,kisspeptin-10 is mainly used for infertility and testosterone replacement therapy, whereas gonadorelin is mainly used to induce ovulation in women. This is the basic difference between kisspeptin-10 and gonadorelin.
FAQ: Kisspeptin-10 vs Gonadorelin
1. What is kisspeptin used for?
- Kisspeptins are proteins encoded by the KISS1 gene in humans. Kisspeptins play essential roles in reproductive health. They are peptides involved in utero sexual development and determine the onset of puberty.
2. Why do men take kisspeptin?
- Kisspeptin may enhance sexual arousal for men with hypoactive sexual desire disorder. Kisspeptin can help to raise testosterone levels in males and is an alternative to testosterone replacement therapy.
3. How long does it take for kisspeptin 10 to work?
- Recent studies revealed intravenous injections of kisspeptin-10 elicited a rapid increase in LH in people with peak concentrations seen by 45 minutes after the injection.
4. What is gonadorelin used for?
- Gonadorelin is used to test the function of the hypothalamus and pituitary glands. It also helps induce ovulation in women who don’t have regular ovulation and menstrual periods due to insufficient GnRH release from the hypothalamus.
5. What are the side effects of gonadorelin peptide?
- After reconstitution, gonadorelin acetate remains stable for at least 45 days when stored at either 24°C or 37°C. The side effects of gonadorelin include rapid heartbeat, hardening of the skin at the place of injection, itching, pain, redness or swelling of the skin at the place of injection, and skin rashes.
Reference:
1. “Kisspeptin 10 vs HCG and Kisspeptin 10 vs Gonadorelin.” Sports Technology Labs.
2. “Gonadorelin (Intravenous Route, Injection Route) Description and Brand Names.” Mayo Clinic, Mayo Foundation for Medical Education and Research.
Image Courtesy:
1. “LH Regulacion” By Harvey Stevenson, Samuel Bartram, Mikaela Maria Charalambides, Sruthi Murthy, Theo Petitt, Anjali Pradeep, Owen Vineall, Ikenna Abaraonye, Amelia Lancaster, Kanyada Koysombat, Bijal Patel, Ali Abbara – Kisspeptin-neuron control of LH pulsatility and ovulation. Front Endocrinol (Lausanne). 2022; 13: 951938. doi: 10.3389/fendo.2022.951938 (CC BY 4.0) via Commons Wikimedia
2. “Gonadorelin” By User:Edgar181 – Own work (Public Domain) via Commons Wikimedia
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