Compare the Difference Between Similar Terms

Difference Between

Home / Science & Nature / Science / Biology / Biochemistry / Difference Between Fluconazole and Itraconazole

Difference Between Fluconazole and Itraconazole

May 13, 2018 Posted by Madhu

The key difference between Fluconazole and Itraconazole is that though both are antifungal medications, fluconazole is not active against Aspergillus whereas Itraconazole is active against Aspergillus. Therefore, itraconazole has a broad range of activity than fluconazole.

The trade name of fluconazole is Diflucan, and the trade name of itraconazole is Sporanox.

Difference Between Fluconazole and Itraconazole - Comparison Summary

CONTENTS

1. Overview and Key Difference
2. What is Fluconazole
3. What is Itraconazole
4. Side by Side Comparison – Fluconazole vs Itraconazole in Tabular Form
5. Summary

What is Fluconazole?

Fluconazole is an antifungal medication for treating fungal infections including candidiasis, blastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, dermatophytosis, and pityriasis versicolor. The chemical formula of fluconazole is C13H12F2N6O, and the molar mass is 306.27 g/mol. The melting point is around 138-140°C.

Difference Between Fluconazole and Itraconazole

Figure 01: The Skeletal Structure of Fluconazole

Fluconazole falls into the class of azoles, which are antifungals. However, it is different from other azole antifungals by the presence of a triazole ring instead of an imidazole ring (as in other azoles). In addition, fluconazole is for the oral use (unlike imidazole antifungals). Fluconazole works best against Candida species, some dimorphic fungi, and dermatophytes.

Side Effects:

Common side effects of fluconazole include rashes, headache, dizziness, nausea, diarrhoea, etc. Some rare side effects include oliguria, seizures, alopecia, liver failure, etc. There are very rare adverse effects as well. Ex: prolonged QT interval.

What is Itraconazole?

Itraconazole is an antifungal medication to treat fungal infections such as aspergillosis, blastomycosis, coccidioidomycosis, histoplasmosis, and paracoccidioidomycosis. The routes of administration are oral or IV (intravenously). Specifically, this medication is useful in treating Aspergillus infections. Moreover, recent studies have shown that this medicine has anticancer properties as well.

The chemical formula of Itraconazole is C35H38Cl2N8O4, and the molar mass is 705.24 g/mol. It has a very complicated chemical structure. This compound shows chirality; thus exist as a racemic mixture. The melting point of Itraconazole is 170°C.

Key Difference Between Fluconazole and Itraconazole

Figure 02: The Chemical Structure of Itraconazole

Side Effects:

The common side effects of Itraconazole include nausea, vomiting, diarrhoea, rash, and headache. There are some rare side effects as well; such side effects include elevated alanine aminotransferase levels, congestive heart failure, liver failure, etc.

What is the Difference Between Fluconazole and Itraconazole?

 Fluconazole vs Itraconazole

Fluconazole is an antifungal medication mainly used to treat infections caused by Candida species, some dimorphic fungi, and dermatophytes. Itraconazole is an antifungal medication mainly used to treat aspergillosis and blastomycosis.
Chemical Formula
C13H12F2N6O. C35H38Cl2N8O4
Molar Mass
306.27 g/mol. 705.24 g/mol.
  Melting Point
Around 138-140°C. 170°C.
Treatment Against Aspergillus Infection
Not active against Aspergillus. Active against Aspergillus.
Side Effects
Rashes, headache, dizziness, nausea, diarrhoea, etc. Nausea, vomiting, diarrhoea, rash, and headache.

Summary – Fluconazole vs Itraconazole

Fluconazole and Itraconazole are two important antifungal medications. The key difference between fluconazole and Itraconazole is that the fluconazole is not active against Aspergillus whereas itraconazole is active against Aspergillus.

Reference:

1. “Itraconazole-A Very Low Bioavailability BCS Class II Drug Case Study.” DisperSol Technologies. Available here 
2. “Fluconazole.” Fluconazole | C13H12F2N6O | ChemSpider. Available here
3. “Fluconazole.” Wikipedia, Wikimedia Foundation, 30 Apr. 2018. Available here 

Image Courtesy:

1.’Fluconazole skeletal formula’By Vaccinationist – PubChem, (Public Domain) via Commons Wikimedia
2.’Itraconazole’By Shaddack – Own work using: ChemWindow, (Public Domain) via Commons Wikimedia 

Related posts:

Difference Between Amino Acid and NucleotideDifference Between Amino Acid and Nucleotide Difference Between Gelatin and PectinDifference Between Gelatin and Pectin Difference Between Ribose and RibuloseDifference Between Ribose and Ribulose Difference Between Pegasys and PegintronDifference Between Pegasys and Pegintron Difference Between Glucocorticoids and CorticosteroidsDifference Between Glucocorticoids and Corticosteroids

Filed Under: Biochemistry

About the Author: Madhu

Madhu is a graduate in Biological Sciences with BSc (Honours) Degree and currently persuing a Masters Degree in Industrial and Environmental Chemistry. With a mind rooted firmly to basic principals of chemistry and passion for ever evolving field of industrial chemistry, she is keenly interested to be a true companion for those who seek knowledge in the subject of chemistry.

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

Request Article

Featured Posts

Difference Between Coronavirus and Cold Symptoms

Difference Between Coronavirus and Cold Symptoms

Difference Between Coronavirus and SARS

Difference Between Coronavirus and SARS

Difference Between Coronavirus and Influenza

Difference Between Coronavirus and Influenza

Difference Between Coronavirus and Covid 19

Difference Between Coronavirus and Covid 19

You May Like

Difference Between Moisturizer and Cream

Difference Between Top 10 Android Apps (Applications)

Difference Between Capricious and Cruel

Difference Between Capricious and Cruel

Difference Between Visitor and Tourist Visa

Difference Between Balance and Scale

Latest Posts

  • What is the Difference Between Osteoporosis and Scoliosis
  • What is the Difference Between Saree and Half Saree
  • What is the Difference Between Hypernatremia and Hyponatremia
  • What is the Difference Between Diabetes Mellitus and Diabetic Ketoacidosis
  • What is the Difference Between Sciatica and Spinal Stenosis
  • What is the Difference Between Metatarsalgia and Morton’s Neuroma
  • Home
  • Vacancies
  • About
  • Request Article
  • Contact Us

Copyright © 2010-2018 Difference Between. All rights reserved. Terms of Use and Privacy Policy: Legal.