Difference Between Estradiol and Estrogen

Estradiol vs Estrogen

Estrogen is a type of steroid sex hormone, which serves in many tissues, affecting both female and male physiology. Estradiol is considered as a type of estrogen. However, there are another two main types of estrogens; estrone and estriol. Estriol is the least effective hormone and found mostly in pregnant females, whereas estrone is the most abundant estrogen hormone in menopause. Estradiol is further described below. The incorporation of three types of estrogen called tri-estrogen, while the incorporation of estriol and estradiol is called bi-estrogen.


Estradiol is the most active type of estrogen that involves in hundreds of activities in the body. It is one of the hormones that have a great effect on the symptom relief for insomnia, headaches, mental fogginess, and fatigue. The estradiol is synthesized in the ovarian granulose cells and is then converted into estriol, the most abundant form of estrogen that is excreted with urine.


Estrogen is considered as the female sex hormone, though it can be found in minute amounts in males, as well. It involves in many organs system, in the body. It mainly plays a role in tissue development and activity, particularly with the tissues and organs associated with the reproductive system including uterus, vagina, mammary gland and hypothalamo- pituitary- gonadal axis.

Additionally, estrogen deficiency may have certain effects on the tissues such as bone, cardiovascular system, and central nervous system. However, the exact mechanisms of action associated with these types of tissues are yet to be understood. When mediating the actions of estrogen, it first binds to the receptors called estrogen receptor (ER). There are two main subtypes of ER, namely; ERα and ERβ. Each of this receptor type is specific for tissue and organ type.

What is the difference between Estradiol and Estrogen?

• Estradiol is the most active and prevalent form of Estrogen.

• Estradiol can be converted into other forms of estrogen through the enzymes.


Further Readings;

1. Difference Between Testosterone and Estrogen

2. Difference Between Progesterone and Estrogen