Compare the Difference Between Similar Terms

Difference Between

Home / Science & Nature / Science / Biology / Biochemistry / Difference Between Glycosylation and Glycosidation

Difference Between Glycosylation and Glycosidation

August 27, 2019 Posted by Dr.Samanthi

The key difference between glycosylation and glycosidation is that glycosylation is the process that attaches a carbohydrate to a protein or a lipid molecule while glycosidation is the process of forming a glycoside.

Glycosylation and glycosidation are two important processes occurring in living organisms. Both glycosylation and glycosidation involve sugar or carbohydrates. During glycosylation, carbohydrates attach with other organic molecules such as proteins or lipids while glycosides formation takes place during glycosidation.

CONTENTS

1. Overview and Key Difference
2. What is Glycosylation 
3. What is Glycosidation
4. Similarities Between Glycosylation and Glycosidation
5. Side by Side Comparison – Glycosylation vs Glycosidation in Tabular Form
6. Summary

What is Glycosylation?

Glycosylation is an enzymatic process that attaches carbohydrate or a glycan to proteins, or other organic molecules such as lipids. The reaction takes place between a glycosyl donor and a glycosyl acceptor, and glycosyltransferases mainly catalyze the reaction between them. Moreover, glycosylation is an important process in proteins (protein glycosylation) to increase their functional properties; it increases protein diversity or the proteome as well. Majority of proteins undergo glycosylation at the rough endoplasmic reticulum and become glycoproteins. Glycosylation especially helps proteins to fold correctly. Moreover, glycosylation makes protein stable when linked with oligosaccharides and facilitates signalling and cell to cell adhesion.

Difference Between Glycosylation and Glycosidation

Figure 01: N-linked Protein Glycosylation

Furthermore, glycosylation is a type of post-translational modification that occurs in proteins. It involves a series of enzymatic steps. N-linked glycosylation, O-linked glycosylation, phosphoserine glycosylation, C-mannosylation and glypiation are several types of glycosylations. Also, the reverse reaction of the glycosylation is deglycosylation. Therefore, deglycosylation refers to the enzymatic reaction of removing glycans from proteins.

What is Glycosidation?

Glycosidation is the formation of glycosides. Glycosides are a wide variety of naturally occurring substances. There is a carbohydrate portion combined with a hydroxyl compound via a glycosidic bond in the glycoside. It is a covalent bond. Therefore, a substance that contains a glycosidic bond is a glycoside, and the glycosidation is the formation process of glycosides.

Main Difference - Glycosylation vs Glycosidation

Figure 02: Glycosidation

In fact, glycosidation is a type of modification of sugar molecules. Removing an aldehyde or ketone group is one way of glycosidation. Therefore, this can be done by reacting the sugar with either alcohol or amines.

What are the Similarities Between Glycosylation and Glycosidation?

  • In both processes, a carbohydrate molecule is in an interaction with another molecule.
  • Both are important biochemical processes occurring in living organisms.

What is the Difference Between Glycosylation and Glycosidation?

Glycosylation converts a carbohydrate into a glycoprotein or glycolipid while glycosidation converts a carbohydrate into a glycoside. Therefore, glycosylation is the enzymatic reaction that attaches a carbohydrate with another organic compound such as protein or lipid. On the other hand, glycosidation is the formation of a glycoside by forming a glycosidic bond. So, this is the key difference between glycosylation and glycosidation.

Difference Between Glycosylation and Glycosidation - Tabular Form

Summary – Glycosylation vs Glycosidation

In summarizing the difference between glycosylation and glycosidation, glycosylation is an enzymatic process that links a carbohydrate or a glycan to proteins, or other organic molecules such as lipids. Glycosidation is the process that forms glycosides by forming a glycosidic bond between carbohydrate and a hydroxyl compound, especially with an alcohol or amines.

Reference:

1. “Glycosylation: Thermo Fisher Scientific – US.” Glycosylation | Thermo Fisher Scientific – US, Available here.

Image Courtesy:

1. “Glicoprotein” By Kosi Gramatikoff, User:Stannered – en:Image:Glicoprotein.jp (Public Domain) via Commons Wikimedia
2. “Ethyl-glucoside” By AxelBoldt at English Wikipedia – Transferred from en.wikipedia to Commons by Common Good using CommonsHelper (Public Domain) via Commons Wikimedia

Related posts:

Difference Between Carbohydrates and ProteinsDifference Between Carbohydrates and Proteins Difference Between Amino Acid and NucleotideDifference Between Amino Acid and Nucleotide Difference Between Gelatin and PectinDifference Between Gelatin and Pectin Difference Between Protease and ProteinaseDifference Between Protease and Proteinase Difference Between Lipoprotein and ApolipoproteinDifference Between Lipoprotein and Apolipoprotein

Filed Under: Biochemistry

About the Author: Dr.Samanthi

Dr.Samanthi Udayangani holds a B.Sc. Degree in Plant Science, M.Sc. in Molecular and Applied Microbiology, and PhD in Applied Microbiology. Her research interests include Bio-fertilizers, Plant-Microbe Interactions, Molecular Microbiology, Soil Fungi, and Fungal Ecology.

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

Request Article

Featured Posts

Difference Between Coronavirus and Cold Symptoms

Difference Between Coronavirus and Cold Symptoms

Difference Between Coronavirus and SARS

Difference Between Coronavirus and SARS

Difference Between Coronavirus and Influenza

Difference Between Coronavirus and Influenza

Difference Between Coronavirus and Covid 19

Difference Between Coronavirus and Covid 19

You May Like

Difference Between EBIT and EBITDA

What is the Difference Between Hemothorax and Pleural Effusion

What is the Difference Between Hemothorax and Pleural Effusion

Difference Between Insolation and Terrestrial Radiation

Difference Between Insolation and Terrestrial Radiation

What is the Difference Between Ethyl Nitrite and Nitroethane

What is the Difference Between Ethyl Nitrite and Nitroethane

Difference Between Raw Honey and Honey

Latest Posts

  • What is the Difference Between Diphtheria and Whooping Cough
  • What is the Difference Between Polyester and Satin
  • What is the Difference Between Syphilis and Gonorrhea
  • What is the Difference Between Stainless Steel and Sterling Silver
  • What is the Difference Between Infrared and Induction Cooker
  • What is the Difference Between Polyester and Viscose
  • Home
  • Vacancies
  • About
  • Request Article
  • Contact Us

Copyright © 2010-2018 Difference Between. All rights reserved. Terms of Use and Privacy Policy: Legal.